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Thanks for the advices.
The FTDI board is set to use 3.3V.
On my FTDI I soldered an additional pin to the 5V, and connected that to the LoPy 5V,
Connected the FTDI to LoPy with GND-GND, RX-TX and TX-RX.
Connected the "G23", this is the 4th pin next to the TX/RX on the LoPy, to GND. This G23 = P2 = GPIO0, see https://forum.pycom.io/assets/uploads/files/1490693421335-index.jpeg
Now the download worked fine using the PyCom Firmware Update tool.