@geobike, to further reply your question:
if you have two LoPys that you want to work with on the same host computer, can we expect to reach them with a common device specification such as/dev/cu.usbserial-DQ008D4O. Or will the host OS set up a separate usbserial device for each board? I understand that each device will have a unique wifi identification.
Each expansion board has an USB to serial port, and the final part of the name is related to that chip. If you swap LoPys over the same expansion board, you'll be able to connect to them over the same /dev/.... string.
If you plug two expansion boards at the same time, they'll indeed appear with different names (different serial ports). The MAC addresses are used for the WiFi part, so each device has it's own access point name (SSID).
I'm refering to expansion boards, but is the same with any kind of USB-to-serial adaptor you can have.
Hope this was helpful for now, if you have more questions, please ask them :)